Pfizer is making significant investment in the creation of novel, first-in-class therapeutics, by combining internal discovery and validation of drug targets with external partnerships to produce clinical drug candidates for the Pfizer pipeline. This position is within a newly created Emerging Sciences Biology (ESB) group within Target Sciences (TS). Target Sciences has expertise in human genetics, functional genomics, automated analytic capabilities and data management, and target validation biology. Target Sciences works together with Pfizer’s nationwide Centers for Therapeutic Innovation (CTI) within Pfizer broader External Science & Innovation group to deliver a broad and deep pipeline of drug candidates, based on emerging science in the academic world.
The primary responsibility of the newly created Emerging Science Biology team is to play a driving role in addressing the critical task, identified as a gap, of rejuvenating the WRD pipeline with innovative, differentiated First-In-Class/ Only-In-Class programs in the years to come. This will be addressed by generation of strong data packages from target hypotheses derived from academic outreach and initiatives incl. ITENs, from human genetics, functional genomics and data mining to enable the initiation of new CTI and RU projects.
This position requires deep expertise in human disease biology, a proven track record in managing target discovery and validation projects in a drug discovery setting, capability to execute, strong leadership skills, and the ability to network effectively at both a senior and hand- on level with CTI and RU biologists and Partner line scientists as well as with external academic PIs.
- Key Deliverable:
- Leads scientific activities and projects for the design and execution of target validation studies defining confidence-in-rationale for potential drug targets and the pathway to pursue them in partnership with TS, CTI, Research Units, and Partner Line colleagues and external academics. This will include oversight of experimental work and hands on experimentation.
- Establish strong data sets enabling objective decision making on specific prospective targets. Target candidates are discovered primarily through the hypothesis generation engine of Target Sciences but could also come from other sources.
- Collaborate successfully within a dynamic and agile group within the broader External Science and Innovation departmental structure and key partners to produce target packages for first-in-class drug discovery programs.
- While the primary responsibility will be to execute target validation plans to drive portfolio entry, it is expected that the incumbent to this role has high scientific and ethical standards and will produce outstanding work that will result in publication in top journals.
- PhD, postdoctoral training, and 4+ years’ experience in basic biology, genomics and/or pharmacology or a closely related discipline.
- 2 years’ industrial experience using genomic, cell biological and/or biochemical technologies to drive drug discovery in a pharmaceutical / biotech setting is highly preferred
- Deep knowledge of cellular and molecular biology and biochemistryand at least one human disease area, with as strong preference for immunology and oncology
- Strong track record of basic biology mechanistic research ideally demonstrated in the context of leading target discovery and validation projects and reflected in a strong record of achievement in peer-reviewed publications.
- Overseeing or experience from collaborations with external academic and biotech resources is a plus.
- Excellent leadership, collaboration, communication, and organizational skills, and ability and desire to work as part of a team dedicated to innovation.
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EEO & Employment Eligibility
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Other Job Details:
- Eligible for Relocation Package
- Eligible for Employee Referral Bonus
N (Other) (United States of America)
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