The research goal of the Trivedi lab is to identify cellular processes and regulatory mechanisms involved in congenital and adult cardiovascular diseases.
Although transcription factors involved in cardiovascular development have been described, the closely associated chromatin modifiers of this process remain largely unknown. Histone deacetylases (Hdacs) modify chromatin structure to regulate gene expression in the heart and vasculature. Using knockout and transgenic murine models, we have characterized chromatin modifying enzymes and signaling pathways critical for lymphatic vascular disease (The Journal of Clinical Investigation), congenital heart defects (JBC), cardiac progenitor cell differentiation (Human Molecular Genetics), cardiomyocyte proliferation (Developmental Cell, JBC), craniofacial defects (Developmental Dynamics), and hypertrophic cardiomyopathy (Nature Medicine).
We seek a highly motivated individual to lead our experimental operation. In this role you will mentor graduate students and work together with postdoctoral fellows in the design, analysis and interpretation of methods to understand gene regulation and developmental processes.
GENERAL SUMMARY OF POSITION:
Under the general direction of the Principal Investigator or designee, the Research Associate II performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.
- Perform complex laboratory experiments and conduct in-depth analysis of research experiments
- Write standard operating procedures, schedule work, analyze data, maintain accurate records, and write reports
- Report the status of projects and observations to the Department Chair
- Ensure departmental computer resources remain functional and provide on-site support to Investigators as requested
- Design and execute protocols and experiments, modify protocols as needed, and may be responsible for own research project
- Manage laboratory research staff
- Responsible for overall laboratory organization including oversight of safety protocols and the maintenance of related records
- May assist with budget and/or operational aspects of grant and contract proposals
- Long-range planning for laboratory and departmental equipment maintenance and replacement. Assist in procurement of departmental equipment. Responsible for physical inventory of all equipment, and maintaining records of all equipment acquired, moved off-site, or discarded
- Oversee and coordinate the use of centralized departmental facilities
- Work with Facilities Engineering, Environmental Health and Safety, and Radiation Safety to ensure department facilities and laboratories are in compliance with federal, state and institutional regulations
- Assist in writing the text of scientific publications and grants. Review literature
- Oversee and assist in the training of new laboratory personnel, students, and collaborators
- Comply with all safety and infection control standards
- Perform other duties as required
- Bachelor’s degree in the Biological Sciences, or equivalent experience
- 5 years of relevant research experience
- Knowledge of Microsoft Office products
- Strong ability to analyze complex visual data in a quantitative and objective manner
- Judgment and action skills required to solve commonly encountered problems
Previous experience with mouse colony management, genotyping, tissue isolation, and cell isolation