Senior Scientist - Immunce Cell Signaling & Tissue Microenviroments
The recently-launched Allen Institute for Immunology is seeking an outstanding molecular immunologist to lead target discovery and validation efforts from our longitudinal multi-omics immune profiling research in cancer and autoimmunity.� Specific responsibilities to include working synergistically with our molecular biology team to drive screening toolbox creation and delivery of novel in vitro and ex vivo immunologic assay techniques.
The successful candidate will have a strong background in applying advanced molecular biology & biochemical techniques to answer fundamental questions in the immunologic field with a track record of both individual and team contributions in solving complex research problems. Strongest consideration will be given to candidates with a proven history of identifying and progressing novel hypotheses forward in discovery research and/or translational settings. Hands-on experience customizing tools and assays to follow the science and tease apart immunological mechanisms using cutting-edge technologies such as reporter cell assays, gene signature discovery, high-content imaging, phenotypic screens, lineage fate tracing, targeted mutagenesis, deorphanization and protein-protein interaction mapping, is highly desired. Relevant experiences would also include familiarity with high-dimensional flow cytometry, CYTOF, single cell transcriptomics, epigenetics and tissue transcriptomics. Bioinformatics expertise and ability to create high impact visualizations are considered a plus.
Reporting to the Director of Experimental Immunology at the Allen Institute, the ideal candidate is a self-motivated team player who is willing to push the boundaries of human immunological research through scientific leadership, individual and team contributions and continuing scholarship on the ever-changing immunological landscape. The successful candidate will also have an established external network in immunology and excellent communication skills that can represent our efforts to our stakeholders internally and in external forum.
The Allen Institute offers exceptional working conditions, and nurtures diversity and team-science in an intellectually rich and stimulating setting. We provide a highly collaborative research environment offering the opportunity to interface closely with our molecular biologists, bioinformaticians, and partner institutions. Together we will unravel key mechanistic pathways of the human immune system across autoimmune disease and cancer. For further details around the Institute�s research plans and partners: https://alleninstitute.org/what-we-do/immunology/.
- PhD and/or MD in immunology, biochemistry, molecular biology or related discipline
- 7+ years post-doctoral research experience in immunology, biochemistry, molecular biology or related discipline in either an academic or drug development setting
- Strong reputation for delivering cutting-edge research as evidenced by high impact publications and dogma shifting contributions to the field or multiple contributions to a drug development pipeline
- Demonstrated excellence creating biochemical or molecular tools to drive target discovery & validation efforts in a research or translational settings including proficiency building out advanced experimental approaches in high-throughput cellular reporter assays, qPCR, siRNA/shRNA target modulation, molecular cloning, and/or lentiviral induced gene expression�
- Proven record of tracking and meeting goals/milestones across multiple projects
- Exceptional oral and written communication skills
- Direct experience in reporter cell assays, high-content imaging, phenotypic screens, lineage fate tracing, targeted mutagenesis, deorphanization and protein-protein interaction mapping is highly desired
- Highly regarded as a mentor for junior and cross-discipline scientists
- Functional knowledge of cytokine networks, gene signature discovery, and in vivo immune cell trafficking
- Proven ability to drive meaningful data visualization from large data sets and work synergistically with bioinformaticians/systems biology teams
- Able to work independently as well as in a collaborative high paced environment
- Bold and detail-oriented scientific spirit with a passion for building out novel tools for the immunology community
It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.